Toxicology (In-vivo)

• Acute
  • Acute (All routes of administration) (OECD 402, 420, 423, 425)
  • Skin Irritation / Sensitisation (OECD 406)
  • Dermal Irritation / Corrosion (OECD 404)
  • Eye Irritation (OECD 405)
• Dose Range Finding (DRF) / Maximum Tolerated Dose (MTD)
• Sub-Acute (OECD 407)
• Sub-Chronic (OECD 408,409)
• Reproductive Toxicity
  • Male Fertility
  • Prenatal Development / Teratology (OECD 414)
  • One Generation Reproduction (OECD 415)
• Toxicokinetics (OECD 417)

Toxicology (In-vitro)

• Cytotoxicity Assay (MTT Assay) (ISO 10993-5:2009(E))
• 3T3-NRU Assay (OECD 432)
• HET-CAM Test

Mutagenicity

• Bacterial Reverse Mutation Test (AMES Test) (OECD 471)
• In Vitro Mammalian Chromosome Aberration Test (OECD 473)
• Mammalian Erythrocyte Micronucleus Test (OECD 474)
• Mammalian Bone Marrow Chromosome Aberration Test (OECD 475)
• In Vitro Mammalian Cell Gene Mutation Test (OECD 476)
• In Vitro Mammalian Cell Micronucleus Test (OECD 487)